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To date, numerous studies have been attempted to determine the extent of variation in evolutionary rates between human disease and nondisease ND genes. In our present study, we have considered human autosomal monogenic Mendelian disease genes, which were classified into two groups according to the number of phenotypic defects, that is, specific disease SPD gene one gene: one defect and shared disease SHD gene one gene: multiple defects. Group-to-group evolutionary rate differences remain statistically significant regardless of their gene expression levels and number of defects.
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